UCM
Research/art/teacher profile of a person
Name and surname:
 prof. Mgr. Daniel Mihálik, PhD.
Email:
 daniel.mihalik@ucm.sk
Homepage:
 http:\\
Fakulta/Univerzita:
FPV UCM - Faculty of Natural Sciences
Pracovisko:
UBB - Ústav biológie a biotechnológie

I. - Basic information

I.1 - Surname
Mihálik
I.2 - Name
Daniel
I.3 - Degrees
Prof. Mgr. PhD.
I.4 - Year of birth
1972
I.5 - Name of the workplace
Department of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava
I.6 - Address of the workplace
Námestie J. Herdu 577/2, 917 01 Trnava, Slovakia
I.7 - Position
Prof.
I.8 - E-mail address
daniel.mihalik@ucm.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/10269
I.10 - Name of the study field in which a person works at the university
Biotechnology/ biology
I.11 - ORCID iD
0000-0002-3719-8634

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.a - Name of the university or institution
Department of Biochemistry, Faculty of natural sciences, University of Commenius in Bratislava
II.b - Year
1994
II.c - Study field and programme
Biochemistry
II.2 - Second degree of higher education
II.a - Name of the university or institution
Department of Biochemistry, Faculty of natural sciences, University of Commenius in Bratislava
II.b - Year
1996
II.c - Study field and programme
Biochemistry
II.3 - Third degree of higher education
II.a - Name of the university or institution
Constantine the philosopher Univesity, Faculty of Natural sciences
II.b - Year
2009
II.c - Study field and programme
Applied biology
II.4 - Associate professor
II.a - Name of the university or institution
University of Ss. Cyril and Methodius in Trnava
II.b - Year
2019
II.c - Study field and programme
Molecular Biology
II.5 - Professor
II.a - Name of the university or institution
UCM Trnva, Faculty of Natural Sciences
II.b - Year
16.3.2024
II.c - Study field and programme
Molecular biology
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
scientific researcher Research Institute of nutrition, Bratislava 1996-1999
researcher Slovgen 1999-2000
scientific researcher University clinic Muenster (WWU), Germany 2001-2004
senior researcher National Agricultural and Food centre, Research Institute of Plant Production, Piešťany 2005 - until now
associated professor University of Ss. Cyril and Methodius in Trnava 2015 - until now

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
scientific degree II.a Slovak academy of sciences 2009

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
KBT/md302/21L laboratory exercise in advanced techniques of molecular biology Biotechnology Master Biotechnology
KBIO/bd207/15 gene manipulations Biotechnology bachelor Biotechnology
KBT/dd06/18 plant biotechnology for PhD students Biotechnology PhD Biotechnology
KBT/bd349/21P methods and techniques of gene manipulations Biotechnology bachelor Biotechnology
KBT/bd320/21P principles of molecular biology Biotechnology bachelor Biotechnology
KBT/bd321/21L Laboratory exercise in molecular biology Biotechnology bachelor Biotechnology
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.3.a - Name of the field of habilitation procedure and inaugural procedure V.3.b - Study field to which it is assigned
Molecular biology Biology
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.a - Bachelor's (first degree)
1
V.4.b - Diploma (second degree)
1
V.4.c - Dissertation (third degree)
1
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
5
V.4.b - Diploma (second degree)
7
V.4.c - Dissertation (third degree)
4
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
KBT/bd349/21P Methods and techniques of gene manipulation Biotechnology bachelor biotechnology
KBT/bd320/21P Principles of Molecular Biology Biotechnology bachelor Biotechnology
KCH/bd265/21P biochemistry chemistry Bachelor Chemistry
KBT/bd323/21P biochemistry Biotechnology Bachelor Biotechnology
KBT/bd523/21P general biochemistry applied biology bachelor applied biology
KBT/md302/21L laboratory exercise in advanced techniques of molecular biology biotechnology master biotechnology

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
67
VI.1.b - Over the last six years
20
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
65
VI.1.b - Over the last six years
20
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
1912
VI.1.b - Over the last six years
827
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
1298
VI.1.b - Over the last six years
571
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
8
VI.1.b - Over the last six years
1
VI.2 - The most significant research/artistic/other outputs

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages /.In: The Journal of clinical investigation. - ISSN 0021-9738. - Vol. 115, iss. 8 (2005), pp. 2223-2233.

 Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial

cells and in anti-thy-1glomerulonephritis / In: Journal of the American Society of Nephrology. - ISSN 1046-6673. - Vol. 16, iss. 7 (2005), pp. 1948-1957

Biotechnology for the functional improvement of cereal-based materials enriched with PUFA and pigments / In: European journal of l ipid science and technology : EJLST. - ISSN 1438-7697. - Vol. 115, iss. 11 (2013), pp. 1247-1256

Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury / In: The American journal of pathology. - ISSN 0002-9440. - Vol. 165, no. 2 (2004), pp. 383-396.

 

Transgenic barley producing essential polyunsaturated fatty acids / In: Biologia plantarum. - ISSN 0006-3134. - Vol. 58, iss. 2 (2014). pp. 348-354.


VI.3 - The most significant research/artistic/other outputs over the last six years

Plant Viruses InfectingSolanaceaeFamily Members in the Cultivated and Wild Environments: A Review / Richard Hančinský, Daniel Mihálik, Michaela Mrkvová, Thierry Candresse, Miroslav Glasa, 2020. DOI DOI 10.3390/plants9050667.

In: Plants-Basel. - ISSN 2223-7747 (online), Roč. 9, č. 5 (2020), s. [1-17] [online].

Evaluation of New Polyclonal Antibody Developed for Serological Diagnostics of Tomato Mosaic Virus [electronic] / Michaela Mrkvová, Richard Hančinský, Simona Grešíková, Šarlota Kaňuková,  Ján Barilla,  Miroslav Glasa,  Pavol  Hauptvogel,  Ján Kraic, Daniel Mihálik, 2022, In: Viruses. - ISSN 1999-4915 (online), Roč. 14, č. 6 (2022), s. [1-15] [online]. IF(2021) = 5,811, Q1

 

High-throughput sequencing reveals bell pepper endornavirus infection in pepper (Capsicum annum) in Slovakia and enables its further molecular characterization [electronic] / Jana Tomašechová, Richard Hančinský, Lukáš Predajňa, Ján Kraic, Daniel Mihálik, Katarína Šoltys, Silvia Vávrová, Miroslav Böhmer, Sead Sabanadzovic, Miroslav Glasa, 2020. DOI DOI 10.3390/plants9010041.

In: Plants-Basel. - ISSN 2223-7747 (online), Roč. 9, č. 1 (2020), s. [1-9] [online].

Mihálik, D. et al. A Novel Isolate of Bean Common Mosaic Virus Isolated from Crownvetch (Securigera varia L. Lassen). In Agronomy. 2023, 13, 7, 1677.

Diacylglycerol Acetyltransferase Gene Isolated from Euonymus europaeus L. Altered Lipid Metabolism in Transgenic Plant towards the Production of Acetylated Triacylglycerols In: Life. - ISSN 2075-1729 (online), Roč. 10, č. 9 (2020), s. [1-16] [online]

 

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Allelic variation of HMW glutenin subunits and 1BL.1RS translocation in Slovak common wheats / Edita Gregová, Daniel Mihálik, Svetlana Šliková, Zuzana Šramková. In: Cereal Research Communications. - ISSN 0133-3720. - Vol. 35, iss. 4 (2007), pp. 1675-1683. [Spoluautori: Daniel Mihálik - Svetlana Šliková - Zuzana Šramková]

Ohlasy: 2009

1] ATANASOVA, D. ...[et al.] Glutenin composition of winter wheat varieties bred in dobrudzha agricultural institute. In Bulgarian Journal of Agricultural, 2009, vol. 15, iss. 1, pp. 9-19. ISSN 1310-0351. 2010

[1] DENG, Z.Y. ...[et al.] Allelic Diversity of HMW and LMW Glutenin Subunits in Chinese Rare Dwarf-Male-Sterile Wheat (Triticum aestivum L.). In Cereal research communications, 2010, vol. 38, iss. 3, pp. 395-405. ISSN 0133-3720. 2013

[1] KONVALINA, P. ...[et al.] BAKING QUALITY AND HIGH MOLECULAR WEIGHT GLUTENIN SUBUNIT COMPOSITION OF EMMER WHEAT, OLD AND NEW VARIETIES OF BREAD WHEAT. In Romanian agricultural research, 2013, vol. 30, pp. 83-89. ISSN 1222-4227. 2014 [1] REHMAN, A. ...[et al.] Lower Tendency of Allelic Variation of Glu Genes and Absence of 1BL-1RS Translocation in Modern Pakistani Wheats. In Cereal research communications, 2014, vol. 42, iss. 1, pp. 139-+. ISSN 0133-3720. 2018

[1] TARIQ, M.J. ...[et al.] Prevelance of higher glutenin variation in synthetic wheat germplasm. In Journal of Animal and Plant, 2018, vol. 28, iss. 2, pp. 568-575. ISSN 1018-7081.

 

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages / Liliana Schaefer ... [et al.]. In: The Journal of clinical investigation. - ISSN 0021-9738. - Vol. 115, iss. 8 (2005), pp. 2223-2233.[Spoluautori: Andrea Babelova - Eva Kiss - Heinz-J. Hausser - Martina Baliova - Miroslava Krzyzankova – Gunther Marsche - Marian F. Young - Daniel Mihálik - Martin Götte - Ernst Malle - Roland M. Schaefer - Hermann Gröne]

Ohlasy:

[1] YAMABA, S., ...[et al.] PLAP-1/Asporin Regulates TLR2-and TLR4-induced Inflammatory Responses. In Journal ofDental Research, 2015, vol. 94, iss. 12, pp. 1706-1714. ISSN 0022-0345. 2016

[ 1] DEGUCHI, A. ...[et al.] Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment. In Oncogene, 2016, vol. 35, iss. 11, pp. 1445-1456. ISSN 0950-9232.

[1] DONG, Huansheng ...[et al.] Cell-Permeable Peptide Blocks TLR4 Signaling and Improves Islet Allograft Survival. In Cell Transplantation, 2016, vol. 25, iss. 7, pp. 1319-1329. ISSN 0963-6897. 2017

[1] KRAM, Vardit ...[et al.] Small leucine rich proteoglycans, a novel link to osteoclastogenesis. In Scientific reports, 2017, vol. 7, art. no. 12627. ISSN 2045-2322. [1] MORTENSEN, J.H. ...[et.al.] Ulcerative colitis, Crohn's disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn's disease. In Plos One, 2017, vol. 12, iss. 10. ISSN 1932-6203. 2018 [1] FALLON, J.R., McNALLY, E.M. Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics. In Matrix biology, 2018, vol. 68-69, pp. 616-627 Special Issue: SI. ISSN 0945-053X.

[1] ITO, M., OHNO, K. Protein-anchoring therapy to target extracellular matrix proteins to their physiological destinations. In Matrix Biology, 2018, vol. 68-69, pp. 628-636, Special Issue: SI. ISSN 0945-053X. [1] NAHON, J.E. ...[et al.] Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model. In Atherosclerosis, 2018, vol. 274, pp. 120-127. ISSN 0021-9150.

Enhanced in vitro propagation of Miscanthus x giganteus / Marcela Gubišová, Jozef Gubiš, Alžbeta Žofajová ... [et al.]. In: Industrial crops and products. - ISSN 0926-6690. - Vol. 41 (2013), pp. 279-282. [Spoluautori: Jozef Gubiš - Alžbeta Žofajová - Daniel Mihálik - Ján Kraic]

Ohlasy:

[1] PHULWARIA, M., SHEKHAWAT, N.S. An efficient in vitro shoot regeneration from immature inflorescence and ex vitro rooting of Arnebia hispidissima (Lehm). DC. - A red dye (Alkannin) yielding plant. In Physiology and Molecular Biology of Plants, 2013, vol. 19, iss. 3, pp. 435-441. ISSN 0971-5894.

[1] RAMBAUND, C. ...[et al.] Shoot organogenesis in three Miscanthus species and evaluation for genetic uniformity using AFLP analysis. In Plant Cell Tissue and Organ Culture, 2013, vol. 113, iss. 3, pp. 437-448. ISSN 0167-6857.

[1] RATHORE, N.S. ...[et al.] In vitro flowering and seed production in regenerated shoots of Cleome viscosa. In Industrial Crops and Products, 2013, vol. 50, pp. 232/236. ISSN 0926-6690. 2014

[1] CICHORZ, S. ...[et al.] Miscanthus: Genetic Diversity and Genotype Identification Using ISSR and RAPD Markers. In Molecular Biotechnology, 2014, vol. 56, iss. 10, pp. 911-924. ISSN 1073-6085. 2015

[1] PERERA, D. ...[et al.] Direct and indirect in vitro regeneration of Miscanthus x giganteus cultivar Freedom: effects of explant type and medium on regeneration efficiency. In In Vitro Cellular & Developmental Biology-Plant, 2015, vol. 51, iss. 3, pp. 294-302. ISSN 1054-5476.

Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-thy-1 glomerulonephritis / Karl-Friedrich Beck ... [et al.]. In: Journal of the American Society of Nephrology. - ISSN 1046-6673. - Vol. 16, iss. 7 (2005), pp. 1948-1957. [Spoluautori: Gülmisal Güder - Liliana Schaefer - Miriam Pleskova - Andrea Babelova - Meik H. Behrens - Daniel Mihálik - Martina Beck - Roland M. Schaefer - Josef Pfeilschifter]

Ohlasy:

[1] FARAONE, D. ...[et al.] Platelet-Derived Growth Factor-Receptor alpha Strongly Inhibits Melanoma Growth In Vitro and In Vivo. In Neoplasia, 2009, vol. 11, iss. 8, pp. 732-U33. ISSN 1522-8002.

[1] ZHANG, Z.Q. Combined use of propranolol and nifedipine offers better effects on portal vein nonuniform remodeling in carbon tetrachloride (CCl4)-induced portal hypertensive rats. In European Journal of Pharmacology, 2009, vol. 613, iss. 1-3, pp. 108-113. ISSN 0014-2999. 2010

[1] KEMPE, D.S. ...[et al.] Akt2/PKB beta-sensitive regulation of renal phosphate transport. In Acta Physiologica, 2010, vol. 200, iss. 1, pp. 75-85. ISSN 1748-1708.

[1] KEMPE, D.S. ...[et al.] Regulation of renal tubular glucose reabsorption by Akt2/PKB beta. In American Journal of Physiology-Renal Physiology, 2010, vol. 298, iss. 5, pp. F1113-F1117. ISSN 1931-857X. 2016

[1] BANDARA, N. ...[et al.] Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells. In Stem Cell Research & Therapy, 2016, vol. 7, art. no. 48. ISSN 1757-6512.

Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells / Liliana Schaefer, Daniel Mihálik ... [et al.]. In: THE JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 0021-9258. - Vol. 278, iss. 28 (2003), pp. 26227-26237. [Spoluautori: Karl-Friedrich Beck - Igor Raslik - Sebastian Walpen - Daniel Mihálik - Miroslava Micegova – Katarina Macakova - Elke Schönherr - Daniela G. Seidler - Georg Varga - Roland M. Schaefer - Hans Kresse - Josef Pfeilschifter]

Ohlasy:

[1] Hutter, R. ...[et al.] Novel Small Leucine-Rich Repeat Protein Podocan Is a Negative Regulator of Migration and Proliferation of Smooth Muscle Cells, Modulates Neointima Formation, and Is Expressed in Human Atheroma. In Circulation, vol. 128, iss. 22, pp. 2351-2363. ISSN 0009-7322. 2014

[1] RYDELL-TOMAEN, K. ...[et al.] Absence of fibromodulin affects matrix composition, collagen deposition and cell turnover in healthy and fibrotic lung parenchyma. In Scientific Reports, 2014, vol. 4, art. no. 6383. ISSN 2045-2322. 2015

[1] WANG, Lei ...[et al.] NF-kappa B protects human neuroblastoma cells from nitric oxide-induced apoptosis through upregulating biglycan. In American Journal of Translational Research, 2015, vol. 7, iss. 9, pp. 1541-1552. ISSN 1943-8141. 2016

[1] FROEHLICH, J.W. ...[et al.] Urinary Proteomics Yield Pathological Insights for Ureteropelvic Junction Obstruction. In Molecular & Cellular Proteomics, 2016, vol. 15, iss. 8, pp. 2607-2615. ISSN 1535-9476.

[1] GASPAR, R. ...[et al.] The cytoprotective effect of biglycan core protein involves Toll-like receptor 4 signaling in cardiomyocytes. In Journal of Molecular and Cellular Cardiology, 2016, vol. 99, pp. 138-150. ISSN 0022-2828. [1] RATLIFF, B.B. ...[et al.] Oxidant Mechanisms in Renal Injury and Disease. In Antioxidants & Redox ignaling, 2016, vol. 25, iss. 3, pp. 119-146. ISSN 1523-0864.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

2017-2021 Metagenomický prístup identifikácie a charakterizácie vírusových ochorení pri vybratých druhoch l iečivých rastlín, APVV-16-0026, zodpovedný riešiteľ: Mgr. Daniel Mihálik, PhD., 250000 EUR

2017-2021 Zlepšenie kvality oleja nepotravinárskych plodín. APVV-16-0051, zodpovedný riešiteľ za UCM, Mgr. Daniel Mihálik, PhD., 62 000 EUR

 

2021 – 2025 Moderné " omics" postupy ako efektívne nástroje pre identifikáciu a charakterizáciu vírusových patogénov strukovín, APVV-20-0015, zodpovedný riešiteľ: doc. Mgr. Daniel Mihálik, PhD., 250000 EUR


 2015-2019 Efektívna diagnostika vírusov ohrozujúcich produkciu rajčiaka jedlého na Slovensku, APVV-14-0055, 250000 EUR, spoluriešiteľ: Mgr. Daniel Mihálik, PhD

 

4.  2022-2027 APVV-21-0289 - Study of the allelopathic and antiviral effects of secondary lichen metabolites, responsible researcher for UCM Trnava

 

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position VII.b - Name of the institution, board VII.c - Duration
member of the scientific council Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava 2021-2022
member of the scientific council Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava 2022-2026
member of the scientific council (whole university) University of Ss. Cyril and Methodius in Trnava 2022-2026
member of the scientific council (whole university) Research Institute of Plant Production 2010-2013

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution VIII.b - Address of the institution VIII.c - Duration (indicate the duration of stay) VIII.d - Mobility scheme, employment contract, other (describe)
WWU Muenster WWU Muesnter, Germany 2001-2004 employment contract
Institute of experimental Botany, Palacký University Olomouc Institute of experimental Botany, Palacký University Olomouc 2007 (5 months) scholarship stay
Institute of experimental Botany, Palacký University Olomouc Institute of experimental Botany, Palacký University Olomouc 2021c(2 months) project cooperation
Institute of experimental Botany, Palacký University Olomouc Institute of experimental Botany, Palacký University Olomouc 2022(2 months) project cooperation

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

utility models, awards:.

1. Primers for the detection of Drechsler tritici-repentis in wheat: useful sample CZ 22600 / Jozef Gubiš, Martina Hudcovicová, Marcela Gubišová, Alžbeta Žofajová, Michaela Havrlentová, Martin Pastirčák, Daniel Mihálik, Katarína Bojnanská, Ján Kraic, P. Matušinsky, L. Cottage cheese. In: Prague : Office of Industrial Property, 2011. - 7 S. [cit. 2012-01-12]. Available at: http://isdv.upv.cz/portal/pls/portal/portlets.pts.det?xprim=1686139&lan=cs

 2. Flour mixture for the preparation of bread and pastries with increased calcium content: Utility model SK 6798 / Marcela Gubišová, Jozef Gubiš, Alžbeta Žofajová, Soňa Gavurníková, Michaela Havrlentová, Katarína Ondreičková, Daniel Mihálik, Mária Lichvárová, Darina Muchová, Ján Kraic. In: Industrial Property Office of the Slovak Republic, 2014. – 4 S. Available at:

http://registre.indprop.gov.sk/registre/pdf/uv/6000/6798.pdf Award Zlatý Kosák 2015 for the methodological manual "Determination of tomato mosaic virus by modern molecular-biological methods"


Date of last update
2025-02-16